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Kirill Morozov
Kirill Morozov

Wire Room 2022 1h 37m 3.5



To interrogate the role of SCVsx2::Hoxa10 neurons after EESREHAB, we augmented our wireless system for spinal cord optogenetics with electrodes40. On the same epidural implant, we integrated both red-shifted microLEDs to deliver deeply penetrating photostimulation and electrodes to enable walking with EES (Extended Data Fig. 15a). Optogenetic inactivation of SCVsx2::Hoxa10 neurons in mice with SCI instantly suppressed walking enabled by EES. Walking resumed immediately when the microLEDs were turned off (Fig. 4a, Extended Data Fig. 15a,b and Supplementary Video 5). We confirmed these results using chemogenetic inactivation (Fig. 4b and Extended Data Fig. 15c). Conversely, activation of SCVsx2::Hoxa10 neurons with chronic paralysis instantly phenocopied the essential elements of the recovery of walking observed in mice that had undergone EESREHAB, regardless of whether EES was switched on or off (Fig. 4c, Extended Data Fig. 15d and Supplementary Video 5). In turn, chronic chemogenetic activation of SCVsx2::Hoxa10 neurons in mice that underwent rehabilitation without EES led to a recovery of walking similar to that in mice that underwent EESREHAB (Extended Data Fig. 15e).




Wire Room 2022 1h 37m 3.5



In humans, EES was delivered using a paddle lead that was surgically implanted over the epidural surface of the lumbar spinal cord. The first 6 participants were implanted with the Specify 5-6-5 paddle lead, which was originally designed to target the dorsal column in order to alleviate pain (Specify 5-6-5, Medtronic). The last three participants were implanted with a new paddle lead that was specifically developed to target the dorsal roots involved in the control of trunk and leg movements18 (ONWARD Medical). The paddle leads were connected to an implantable pulse generator (IPG) (Medtronic Activa RC, Medtronic) commonly used for deep-brain stimulation therapies. We upgraded this IPG with a wireless communication bridge that enabled real-time control over the parameters of EES protocols.


A number of cities across China experienced travel restrictions for a significant part of the first half of 2022. These restrictions on inter-provincial travel impacted visitation to Macau and in turn adversely impacted both revenue and profitability. In addition, Macau experienced a COVID-19 outbreak and the Macau Government requested suspension of all commercial activities from 11 to 22 July 2022 which further impacted visitation, revenue and profitability. In Q2 2022, Group Net Revenue was $2.4 billion, down 56% year-on-year and down 41% quarter-on-quarter. Group Adjusted EBITDA was $(0.4) billion, versus $1.1 billion in Q2 2021 and $0.6 billion in Q1 2022.


Our balance sheet remains liquid and healthy. As of 30 June 2022, cash and liquid investments were $29.0 billion and net cash was $20.3 billion. Core debt remains relatively unchanged at $0.3 billion. This provides us with valuable flexibility in managing operations and supporting our development initiatives. Given the ongoing impact of COVID-19, today the Board of Directors has decided not to declare a dividend. We paid the previously announced special dividend of $0.30 per share on 29 April 2022.


In Q2 2022, due to increased cases of COVID-19 and the associated travel restrictions and quarantine rules, visitor arrivals to Macau were 1.6 million, down 27% year-on-year and down 15% quarter-on-quarter. Visitor arrivals from the Mainland were 1.4 million, down 29% year-on-year and down 18% quarter-on-quarter. Overnight visitors were 0.5 million, down 49% year-on-year and down 14% quarter-on-quarter.


In 1H 2022, GEG experienced good luck in its gaming operation, which increased its Adjusted EBITDA by approximately $27 million. Normalized 1H 2022 Adjusted EBITDA was $164 million, down 91% year-on-year.


In Q2 2022, GEG experienced good luck in its gaming operations which increased Adjusted EBITDA by approximately $24 million. Normalized Q2 2022 Adjusted EBITDA was $(408) million, versus $1.1 billion in Q2 2021 and $572 million in Q1 2022.


Due to our conservative financial management, our balance sheet continues to remain strong. As of 30 June 2022, cash and liquid investments were $29.0 billion and net cash was $20.3 billion. Total debt was $8.7 billion which primarily reflects our ongoing treasury yield management initiatives where interest income on cash holdings exceeds corresponding borrowing costs. Core debt remained minimal at $0.3 billion. This provides us with valuable flexibility in managing our ongoing operations and allows us to continue investing in our longer term development plans. Given the ongoing impact of COVID-19, today the Board of Directors has decided not to declare a dividend. We paid the previously announced special dividend of $0.30 per share on 29 April 2022.


We are now firmly focused on the development of Phase 4, which is already well under way. We see the premium market evolving with this segment preferring higher quality and more spacious rooms. We continue to proceed with the construction of Cotai Phase 4, our next generation integrated resort, which will complete our ecosystem in Cotai.


1 The primary difference between statutory gross revenue and management basis gross revenue is the treatment of City Clubs revenue where fee income is reported on a statutory basis and gross gaming revenue is reported on a management basis (only up to 26 June 2022). At the Group level the gaming statistics include Company owned resorts plus City Clubs.


8 The primary difference between statutory gross revenue and management basis gross revenue is the treatment of City Clubs revenue where fee income is reported on a statutory basis and gross gaming revenue is reported on a management basis (only up to 26 June 2022). At the Group level the gaming statistics include Company owned resorts plus City Clubs.


The 2022 Acura MDX, the fourth-generation of America's best-selling three-row luxury SUV of all-time, undergoes its most radical transformation since the launch of the first generation model 20 years ago. A quantum leap forward with a bold exterior design and sophisticated and elegant new interior, MDX achieves its highest level of performance, technological and premium appeal to assume its new role as the flagship of the Acura lineup.


For the first time, the 2022 MDX applies an Active Shutter Grille. In certain conditions, shutters in the lower grille close to divert air around the vehicle, thereby reducing aerodynamic drag. When the demand for cooling air increases, the shutters reopen.


Even with the addition of a standard ultra-wide panoramic moonroof, the all-new platform's innovative roll-hemmed roof construction, wider body and longer wheelbase offers more headroom for the first and third-row occupants, in addition to more legroom, shoulder room and total passenger volume in all three rows. In the second row, MDX features a first-in-class multifunction second row with removable middle seat, which, when removed, enables easy passenger access to the third row, even when child seats are installed in the outboard second row seats.


First introduced in the all-new 2021 TLX, the new 2022 MDX incorporates Acura's award-winning next-generation passenger front airbag technology. With three inflatable chambers and an uninflated "sail panel" stretched between the two side chambers, the new airbag is designed to initially catch and decelerate the occupant's head with less force prior to contacting the lower chamber, cradling helping protect the front seat passenger's head to mitigate potential injury, especially in angled frontal collisions.


The 2022 MDX targets a 5-Star Overall Vehicle Score from the National Highway Traffic Safety Administration (NHTSA), and incorporates anticipated future testing requirements, including oblique frontal collisions, pedestrian safety, and forward warning and automatic emergency braking tests. In addition, the new MDX targets a TOP SAFETY PICK+ rating from the Insurance Institute for Highway Safety (IIHS), including the highest available rating of GOOD in all collision tests and SUPERIOR for frontal crash prevention, with new headlights designed to achieve a GOOD rating in the rigorous IIHS headlight standard.


Design, Development and ManufacturingThe 2022 Acura MDX joins its three predecessors in being designed, engineered and developed in America. Styling was led by the Acura Design Studio in Torrance, Calif., while full platform and vehicle development was led by engineers in the company's development center in Raymond, Ohio. The all-new MDX will continue to be built exclusively at the company's auto plant in East Liberty, Ohio, using domestic and globally sourced parts, while the 3.5-liter V6 is produced at the company's Anna, Ohio, engine plant. Acura's 10-speed automatic transmission is built exclusively at the company's Tallapoosa, Ga., transmission plant.


Based on the Integrated Dynamics System setting, one of three different drive-by-wire maps is used. Normal and Comfort use a map suited for all-around driving, while Sport mode uses an aggressive map for performance driving. The new Snow mode features a gradual map to aid driving in slippery conditions.


The 2022 MDX uses new control logic for more intuitive Idle-Stop operation. Previously, when the driver brought the vehicle to a stop, the MDX engine would automatically stop; however, when the driver selected "P" (Park), the engine would sometimes restart. Now, in this situation, the engine remains off.


10-Speed Automatic Transmission For the first time, the 2022 MDX is equipped with Acura's in-house developed 10-speed automatic transmission (10AT) that yields notable improvements in engine performance and efficiency and shift performance.


Shift-By-Wire Gear SelectorThe 2022 MDX uses a fully electronic, shift-by-wire gear selector. Park, Neutral and Drive are selected with the push of a button. Reverse is selected by pulling back a dedicated switch. Indicator lights on or next to the buttons show the selected mode. Also, if the vehicle is brought to a stop in Drive or Reverse, the system will automatically select Park if the driver's seatbelt is unbuckled and the driver's door is opened. Steering wheel-mounted paddle shifters let the driver take manual control of transmission gear selection. 041b061a72


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